反应详情

To the above solution of 1-adamantylmethyl isocyanate was added a solution of 5-fluorouracil (2.60 g) in N,N-dimethylacetamide (20 ml) at 80° C. and stirred for further 3 hours at the same temperature. The resultant mixture was diluted with ethyl acetate (200 ml), washed with water (each 30 ml., 3 times), dried over magnesium sulfate, treated with activated charcoal, filtered and evaporated in vacuo. The residue was recrystallized from diethyl ether to give 1-[N-(1-adamantylmethyl)carbamoyl]-5-fluorouracil (1.85 g), as colorless crystalline powder.

1. washwashed with water (each 30 ml
2. dry with material, 3 times), dried over magnesium sulfate
3. additiontreated with activated charcoal
4. filtrationfiltered
5. customevaporated in vacuo
6. customThe residue was recrystallized from diethyl ether