Triethylamine → HCID 20525106, compound

HRID 1702785Notes

Reaction equation

HRID 1702785 reaction equation
[C:1]([CH2:3][CH2:4][S:5][CH2:6][CH2:7]C(O)=O)#[N:2].C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:18])C=CC=CC=1.C([N:30]([CH2:33]C)CC)C>C1C=CC=CC=1>[C:1]([CH2:3][CH2:4][S:5][CH2:6][CH2:7][N:30]=[C:33]=[O:18])#[N:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 199401P,P-Diphenylphosphinic azideHCID 20525116HCID 20525116, compound

Product 1

HCID 20525106HCID 20525106, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

The reaction of 3-(2-cyanoethylthio)propionic acid and diphenylphosphoryl azide in a solution of triethyl amine and benzene provided a solution comprising 2-(2-cyanoethylthio)ethyl isocyanate (I.R.: 2250 cm-1), which was reacted with 5-fluorouracil to provide 1-[N-[2-(2-cyanoethylthio)ethyl]carbamoyl]-5-fluorouracil substantially in the similar method to that of Example 10.

Sources & evidence

ORD record
ord-56efb58428d4466488393972f7d4e1b4
Source dataset
uspto-grants-1982_09
Patent number
US04349552

Reaction notes

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