Tetrahydrofuran → tert-Butyl 4-(4-{[(5-chloro-2-thienyl)carbonyl]amino}-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)tetrahydro-1(2H)-pyridinecarboxylate

HRID 170279Notes

Reaction equation

HRID 170279 reaction equation
[CH2:66]1[O:67][CH2:68][CH2:69][CH2:70]1.[Cl:13][c:14]1[cH:15][cH:16][c:17]([C:19](=[O:20])[NH:21][c:22]2[c:23]3[c:27]([cH:28][cH:29][cH:30]2)[C:26](=[O:31])[NH:25][C:24]3=[O:32])[s:18]1.[O:1]=[C:2]([O:3][CH2:4][CH3:5])[N:6]=[N:7][C:8]([O:9][CH2:10][CH3:11])=[O:12].[OH:33][CH:34]1[CH2:35][CH2:36][N:37]([C:40](=[O:41])[O:42][C:43]([CH3:44])([CH3:45])[CH3:46])[CH2:38][CH2:39]1.[c:47]1([P:48]([c:49]2[cH:50][cH:51][cH:52][cH:53][cH:54]2)[c:55]2[cH:56][cH:57][cH:58][cH:59][cH:60]2)[cH:61][cH:62][cH:63][cH:64][cH:65]1>>[Cl:13][c:14]1[cH:15][cH:16][c:17]([C:19](=[O:20])[NH:21][c:22]2[c:23]3[c:27]([cH:28][cH:29][cH:30]2)[C:26](=[O:31])[N:25]([CH:34]2[CH2:35][CH2:36][N:37]([C:40](=[O:41])[O:42][C:43]([CH3:44])([CH3:45])[CH3:46])[CH2:38][CH2:39]2)[C:24]3=[O:32])[s:18]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 41357405-Chloro-N-(1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)thiophene-2-carboxamide

Product 1

HCID 18440735tert-Butyl 4-(4-{[(5-chloro-2-thienyl)carbonyl]amino}-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)tetrahydro-1(2H)-pyridinecarboxylate

Sources & evidence

ORD record
ord-61881a86b700478089e5ec548c2e2ede
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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