Sodium hydride → HCID 12961709, compound

HRID 1702883Notes

Reaction equation

HRID 1702883 reaction equation
[H-].[Na+].[C:3]1([N:9]2[C:13]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:12][NH:11][C:10]2=[O:20])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:21][O:22][C:23](=[O:32])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]Br>CN(C=O)C>[CH3:21][O:22][C:23](=[O:32])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][N:11]1[CH:12]=[C:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:9]([C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)[C:10]1=[O:20]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 11107373Methyl 8-bromooctanoateHCID 12418984HCID 12418984, compound

Product 1

HCID 12961709HCID 12961709, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The product is produced as described in example 1 from 2.34 g of NaH (80% suspension in mineral oil), 18.5 g of 1.5-diphenyl-4-imidazolin-2-one, 160 cc. of DMF, 18.5 g of 8-bromocaprylic acid methyl ester and 2.34 g of NaJ.

Workup

  1. customThe product is produced

Sources & evidence

ORD record
ord-2defbe717b864ad1adccfcdef9729ca7
Source dataset
uspto-grants-1982_09
Patent number
US04349684

Reaction notes

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