Sodium hydride → HCID 53874415, compound

HRID 1702885Notes

Reaction equation

HRID 1702885 reaction equation
[H-].[Na+].[C:3]1([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=3)[C:12](=[O:24])[NH:11][CH:10]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:25][O:26][C:27](=[O:36])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]Br>CN(C=O)C>[CH3:25][O:26][C:27](=[O:36])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][N:11]1[CH:10]=[C:9]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:13]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:21])[F:22])[CH:15]=2)[C:12]1=[O:24]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 11107373Methyl 8-bromooctanoateHCID 20525407HCID 20525407, compound

Product 1

HCID 53874415HCID 53874415, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The product is produced as described in example 1 from 1.41 g of NaH (80% suspension in mineral oil), 14.3 g of 5-phenyl-1-(3-trifluoromethylphenyl)-4-imidazolin-2-one, 100 cc. of DMF, 11.1 g of 8-bromocaprylic acid methyl ester and 1.41 g of NaJ.

Workup

  1. customThe product is produced

Sources & evidence

ORD record
ord-5c38c572b1fb437384bb8ba14bc42b6f
Source dataset
uspto-grants-1982_09
Patent number
US04349684

Reaction notes

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