Hydrazine hydrate (1:1) → HCID 178514357, compound

HRID 1702983Notes

Reaction equation

HRID 1702983 reaction equation
Cl[C:2]1[N:11]=[C:10]([OH:12])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:13]([O-:15])=[O:14])[CH:8]=2)[N:3]=1.O.[NH2:17][NH2:18]>O>[NH:17]([C:2]1[N:11]=[C:10]([OH:12])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:13]([O-:15])=[O:14])[CH:8]=2)[N:3]=1)[NH2:18]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178526469HCID 178526469, compound

Product 1

HCID 178514357HCID 178514357, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The wet product from Step A was dissolved in a mixture of 90 ml hydrazine hydrate and 900 ml of water and the mixture was stirred at 90°-100° C. until crystallization took place. The mixture was allowed to cool and was filtered. The product was washed with water and methanol and dried to obtain 97.2 g of 2-hydrazino-4-hydroxy-6-nitro-quinazoline in the form of a high melting, orange crystalline solid.

Workup

  1. temperatureto cool
  2. filtrationwas filtered
  3. washThe product was washed with water and methanol
  4. customdried

Sources & evidence

ORD record
ord-9b766250c0c140b3869f300058a95630
Source dataset
uspto-grants-1982_09
Patent number
US04350695

Reaction notes

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