Water → HCID 20524567, compound

HRID 1703049Notes

Reaction equation

HRID 1703049 reaction equation
[C:1]1([N:7]2[C:11](=[S:12])[N:10]([CH2:13]Cl)[N:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:15]1(=[O:25])[NH:19][C:18](=[O:20])[C:17]2=[CH:21][CH:22]=[CH:23][CH:24]=[C:16]12.[K].O.C(OCC)(=O)C>CN(C)C=O>[C:1]1([N:7]2[C:11](=[S:12])[N:10]([CH2:13][N:19]3[C:18](=[O:20])[C:17]4=[CH:21][CH:22]=[CH:23][CH:24]=[C:16]4[C:15]3=[O:25])[N:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 15291093HCID 15291093, compoundHCID 24194345Phthalimide potassium salt

Product 1

HCID 20524567HCID 20524567, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 1-phenyl-4-chloromethyltetrazoline-5-thione (4.53 g) and potassium phthalimide (4.00 g) in 50 ml dimethylformamide was heated at 55° C. for 2 hours. The solution was poured into water. Ethyl acetate extractive workup gave a colorless solid. Recrystallization from ethanol afforded a colorless solid, m.p. 130°-134° C. (2.75 g).

Workup

  1. customRecrystallization from ethanol
  2. customafforded a colorless solid, m.p. 130°-134° C. (2.75 g)

Sources & evidence

ORD record
ord-c6425d999e094122a0a275be1c702a92
Source dataset
uspto-grants-1982_09
Patent number
US04350752

Reaction notes

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