Sodium Carbonate → 3-(2-Pyrimidinyl)-3-aza-6-azoniaspiro[5.5]undecane Chloride

HRID 1703342Notes

Reaction equation

HRID 1703342 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[Cl:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]Cl.C(=O)([O-])[O-].[Na+].[Na+]>C(O)(C)C>[Cl-:13].[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:12][CH2:11][N+:10]2([CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)[CH2:9][CH2:8]1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 123531,5-DichloropentaneHCID 887471-(2-Pyrimidinyl)piperazine

Product 1

HCID 132556203-(2-Pyrimidinyl)-3-aza-6-azoniaspiro[5.5]undecane Chloride

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Reaction of 1-(2-pyrimidinyl)piperazine (16.4 g., 0.1 mole), 1,5-dichloropentane (28.2 g., 0.2 mole) and sodium carbonate (21.2 g., 0.2 mole) in 300 ml. of isopropanol according to the procedure of Example 2 affords the title compound.

Sources & evidence

ORD record
ord-79d93dc1146e4cd09dbd559e5f0d8e61
Source dataset
uspto-grants-1982_09
Patent number
US04351939

Reaction notes

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