Hydroxyamine hydrochloride → HCID 54314493, compound

HRID 1703535Notes

Reaction equation

HRID 1703535 reaction equation
[CH2:1]([C:3]1[O:4][C:5]2[CH:16]=[CH:15][CH:14]=[CH:13][C:6]=2[C:7]=1[C:8]([CH3:12])([CH3:11])[C:9]#[N:10])[CH3:2].Cl.[NH2:18][OH:19].C[O-].[Na+]>>[CH2:1]([C:3]1[O:4][C:5]2[CH:16]=[CH:15][CH:14]=[CH:13][C:6]=2[C:7]=1[C:8]([CH3:12])([CH3:11])[C:9](=[N:18][OH:19])[NH2:10])[CH3:2]

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 10942334Sodium MethoxideHCID 12360102HCID 12360102, compound2×

Product 1

HCID 54314493HCID 54314493, compoundYield 41%

Procedure

The above-named compound was prepared from 2-(2-ethyl-3-benzofuranyl)-2-methyl-propionitrile by the procedure described in Example 1(a), but using 1.5 mol of hydroxylamine hydrochloride and sodium methylate for each mole of 2-(2-ethyl-3-benzofuranyl)-2-methylpropionitrile and continuing the reaction for 72 hours. Yield: 41%; m.p. 118°-120° C. after recrystallization from a mixture of ethyl acetate and light petroleum ether.

Workup

  1. customthe reaction for 72 hours
  2. customm.p. 118°-120° C. after recrystallization
  3. additionfrom a mixture of ethyl acetate and light petroleum ether

Sources & evidence

ORD record
ord-043586a2c4b04741b080d30201233875
Source dataset
uspto-grants-1978_11
Patent number
US04124710

Reaction notes

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