反应详情

1-Acetyl-3-hydroxypiperidine (0.10 mole) is dissolved in 50 ml. of dimethylformamide. 0.12 Mole of sodium hydride (56%) is added over a 10 minute period, and the reaction mixture is stirred for 30 minutes. Benzyl chloride (0.12 mole) is added dropwise over a 30 minute period, and the reaction mixture is then heated on a steam bath for 30 minutes. Water (3 volumes) is added, the solution extracted with ether, the ether extract washed with water and the ether removed by evaporation. A yellow oil is obtained on distillation at 136°-140° C. (0.01 mm Hg.).

1. temperaturethe reaction mixture is then heated on a steam bath for 30 minutes
2. extractionthe solution extracted with ether
3. extractionthe ether extract
4. washwashed with water
5. customthe ether removed by evaporation
6. customA yellow oil is obtained on distillation at 136°-140° C. (0.01 mm Hg.)