Ethanol → HCID 86736149, compound

HRID 1703778Notes

Reaction equation

HRID 1703778 reaction equation
Cl.[C:2]([C:17]1[CH:29]=[CH:28][C:20]([N:21]([CH2:25][CH2:26][OH:27])[CH2:22][CH2:23][OH:24])=[CH:19][CH:18]=1)([C:4]1[CH:16]=[CH:15][C:7]([N:8]([CH2:12][CH2:13][OH:14])[CH2:9][CH2:10][OH:11])=[CH:6][CH:5]=1)=[NH:3].C(O)C.C1C=CC2C(C3C=CC(O)=CC=3)(C3C=CC(O)=CC=3)OC(=O)C=2C=1.[OH-].[NH4+]>O>[C:2]([C:17]1[CH:29]=[CH:28][C:20]([N:21]([CH2:25][CH2:26][OH:27])[CH2:22][CH2:23][OH:24])=[CH:19][CH:18]=1)([C:4]1[CH:16]=[CH:15][C:7]([N:8]([CH2:12][CH2:13][OH:14])[CH2:9][CH2:10][OH:11])=[CH:6][CH:5]=1)=[NH:3]

Participants

6

Reactant 4

HCID 702EthanolHCID 4764PhenolphthaleinHCID 14923Ammonium HydroxideHCID 86736148HCID 86736148, compound

Product 1

HCID 86736149HCID 86736149, compoundYield 65.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 80 grams (0.188 mole) of the product of Example 1 is dissolved in 2400 mls. of ethyl alcohol and made alkaline to phenolphthalein indicator paper by adding concentrated ammonium hydroxide thereto. The solution is cooled in an ice bath and diluted with 1200 mls. of ice (5° C.) water. The resulting precipitate is separated by filtration and dried in a vacuum oven to obtain 48 grams of product. This free base is believed to be a new compound and is claimed as such herein.

Workup

  1. temperatureThe solution is cooled in an ice bath
  2. additiondiluted with 1200 mls
  3. customThe resulting precipitate is separated by filtration
  4. customdried in a vacuum oven

Sources & evidence

ORD record
ord-ca3f1a51d1504e958e383fca0337f935
Source dataset
uspto-grants-1978_11
Patent number
US04125557

Reaction notes

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