Hydrochloric Acid → HCID 86736151, compound

HRID 1703796Notes

Reaction equation

HRID 1703796 reaction equation
[NH2:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][N:10]([C:13]3[N:14]=[CH:15][C:16]4[C:22](=[O:23])[C:21]([C:24]([OH:26])=[O:25])=[CH:20][N:19]([CH2:27][CH3:28])[C:17]=4[N:18]=3)[CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[ClH:31]>C(O)C>[ClH:31].[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][N:10]([C:13]3[N:14]=[CH:15][C:16]4[C:22](=[O:23])[C:21]([C:24]([OH:26])=[O:25])=[CH:20][N:19]([CH2:27][CH3:28])[C:17]=4[N:18]=3)[CH2:9][CH2:8]2)=[CH:29][CH:30]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22760700HCID 22760700, compound

Product 1

HCID 86736151HCID 86736151, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

2-[4-(p-Aminobenzyl)-1-piperazinyl]-8-ethyl-5,8-dihydro-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid (3.0 g) was dissolved in 300 ml of ethanol by heating at 80° C. To the hot solution was added 0.5 ml of concentrated hydrochloric acid and the mixture was allowed to stand in a refrigerator. The resulting precipitate was collected by filtration and recrystallized twice from ethanol containing a small amount of concentrated hydrochloric acid to give the product (2.2 g), m.p. above 300° C.

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. customrecrystallized twice from ethanol containing a small amount of concentrated hydrochloric acid

Sources & evidence

ORD record
ord-ea881aa1cf324002b0ca9f0b1657652f
Source dataset
uspto-grants-1978_11
Patent number
US04125615

Reaction notes

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