N,N'-Diethylthiourea → 3-Ethyl-2-ethylimino-4-(4-bromo-3-sulfamoylphenyl)-1,3-thiazolidine-4-ol-hydrochloride

HRID 1703882Notes

Reaction equation

HRID 1703882 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9][Cl:10])=[CH:4][C:3]=1[S:12](=[O:15])(=[O:14])[NH2:13].[CH2:16]([NH:18][C:19]([NH:21][CH2:22][CH3:23])=[S:20])[CH3:17]>>[ClH:10].[CH2:22]([N:21]1[C:8]([C:5]2[CH:6]=[CH:7][C:2]([Br:1])=[C:3]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:4]=2)([OH:11])[CH2:9][S:20][C:19]1=[N:18][CH2:16][CH3:17])[CH3:23]

Participants

3

Reactant 2

HCID 2735009N,N'-DiethylthioureaHCID 227606054'-Bromo-3'-sulfamoyl-2-chloroacetophenone

Product 1

HCID 227605693-Ethyl-2-ethylimino-4-(4-bromo-3-sulfamoylphenyl)-1,3-thiazolidine-4-ol-hydrochloride

Procedure

4.6 g of 4'-bromo-3'-sulfamoyl-2-chloroacetophenone and 1.8 g of ground 1,3-diethylthiourea were reacted and worked up according to the prescription given in Example 12. Colorless solid body, decomposition beginning at 103° C., C=N 1615 cm-1.

Workup

  1. customat 103° C.

Sources & evidence

ORD record
ord-92285eb56dfc49749d4e9385e2fc9f71
Source dataset
uspto-grants-1978_11
Patent number
US04125614

Reaction notes

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