Hydrogen Bromide → HCID 22760637, compound

HRID 1703927Notes

Reaction equation

HRID 1703927 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:26])[CH2:12][S:11][C:10](=[N:13][CH:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)[N:9]2[CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)=[CH:4][C:3]=1[S:27](=[O:32])(=[O:31])[N:28]([CH3:30])[CH3:29].[BrH:33]>CO>[BrH:33].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:26])[CH2:12][S:11][C:10](=[N:13][CH:14]3[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]3)[N:9]2[CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)=[CH:4][C:3]=1[S:27](=[O:32])(=[O:31])[N:28]([CH3:29])[CH3:30]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 22760443HCID 22760443, compound

Product 1

HCID 22760637HCID 22760637, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.5 g of 4-(4-chloro-3-dimethylsulfamoylphenyl)-3-cyclohexyl-2-cyclohexylimino-1,3-thiazolidine-4-ol were dissolved in 10 ml of methanol and adjusted to pH 3 by adding dropwise 48% hydrobromic acid. The solvent was distilled off under reduced pressure and the amorphous end product was crystallized under diethyl ether. Colorless crystals, melting point: 131° C. (decomposition).

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe amorphous end product was crystallized under diethyl ether

Sources & evidence

ORD record
ord-03ce7606ab7043dcb6726681e1dc143c
Source dataset
uspto-grants-1978_11
Patent number
US04125614

Reaction notes

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