Triethylamine → HCID 20378389, compound

HRID 1704140Notes

Reaction equation

HRID 1704140 reaction equation
[F:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH:7]([CH3:10])[CH2:8][OH:9])=[CH:4][CH:3]=1.[CH3:13][S:14](Cl)(=[O:16])=[O:15].C(N(CC)CC)C>ClCCl>[CH3:13][S:14]([O:9][CH2:8][CH:7]([O:6][C:5]1[CH:11]=[CH:12][C:2]([F:1])=[CH:3][CH:4]=1)[CH3:10])(=[O:16])=[O:15]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 104647301-Propanol, 2-(4-fluorophenoxy)-

Product 1

HCID 20378389HCID 20378389, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

As described in Example 56, 7.7 g of 2-(p-fluorophenoxy)-1-propanol is reacted with 8.8 ml of methanesulfonyl chloride in 400 ml of dichloromethane in the presence of 12.5 ml of triethylamine. The product is obtained as a pale yellow liquid.

Workup

  1. customThe product is obtained as a pale yellow liquid

Sources & evidence

ORD record
ord-bd34f44521494b72b6ca31fea84e8c99
Source dataset
uspto-grants-1978_11
Patent number
US04125732

Reaction notes

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