Triethylamine → 2-(p-Fluorophenoxy)ethanol O-methanesulfonate

HRID 1704152Notes

Reaction equation

HRID 1704152 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][C:5]([O:6][CH2:7][CH2:8][OH:9])=[CH:4][CH:3]=1.[CH3:12][S:13](Cl)(=[O:15])=[O:14].C(N(CC)CC)C>ClCCl>[CH3:12][S:13]([O:9][CH2:8][CH2:7][O:6][C:5]1[CH:10]=[CH:11][C:2]([F:1])=[CH:3][CH:4]=1)(=[O:15])=[O:14]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 5743612-(4-Fluorophenoxy)ethanol

Product 1

HCID 203783952-(p-Fluorophenoxy)ethanol O-methanesulfonate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

As for Example 56, 12.5 g of 2-(p-fluorophenoxy) ethanol is reacted with 7 ml of methanesulfonyl chloride in 100 ml of dichloromethane in the presence of 23 ml of triethylamine. The product (18 g) is obtained as a colorless liquid.

Sources & evidence

ORD record
ord-d72bfea152a74cdfaa75511a6c81fb6e
Source dataset
uspto-grants-1978_11
Patent number
US04125732

Reaction notes

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