Hydrogen Bromide → HCID 22759363, compound

HRID 1704377Notes

Reaction equation

HRID 1704377 reaction equation
[CH2:1]([N:3]([CH2:8][CH3:9])[CH2:4][CH2:5][CH2:6]O)[CH3:2].[NH2:10][C:11]([NH2:13])=[S:12].[BrH:14]>>[BrH:14].[BrH:14].[CH2:1]([N:3]([CH2:8][CH3:9])[CH2:4][CH2:5][CH2:6][S:12][C:11](=[NH:10])[NH2:13])[CH3:2]

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 121593-(Diethylamino)-1-propanolHCID 2723790Thiourea

Product 1

HCID 22759363HCID 22759363, compound

Procedure

A mixture of 3-(diethylamino)propyl alcohol (65.5 g), thiourea (38.0 g) and aqueous hydrobromic acid (48%, 25 ml) was boiled under reflux for 17 hours, and evaporated to dryness. The residue was triturated with ethanol and recrystallised from ethanol/methanol to give the title product, m.p. 125°-127° which was further recrystallised from absolute ethanol to give a 10.0 g sample with m.p. 144°-145°.

Workup

  1. temperatureunder reflux for 17 hours
  2. customevaporated to dryness
  3. customThe residue was triturated with ethanol
  4. customrecrystallised from ethanol/methanol

Sources & evidence

ORD record
ord-5b690d23b501404cafdfa4aca8846f35
Source dataset
uspto-grants-1978_11
Patent number
US04126670

Reaction notes

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