反应详情

A mixture of 3-phenoxy-1-chloro-propane (1 mole), sodium iodide (1 mole) and anhydrous piperazine (4 moles) is added to methyl ethyl ketone (1000 ml). The mixture is refluxed during 24 hours, with stirring. The solvent is removed in vacuo over a water-bath and the residue is poured over water. The aqueous phase is extracted with methylene chloride and then washed twice with water. The solvent is removed and the residual oil is distilled. B.p. = 115° C./0.05 mm Hg.

1. temperatureThe mixture is refluxed during 24 hours
2. customThe solvent is removed in vacuo over a water-bath
3. additionthe residue is poured over water
4. extractionThe aqueous phase is extracted with methylene chloride
5. washwashed twice with water
6. customThe solvent is removed
7. distillationthe residual oil is distilled