4-Bromotoluene → HCID 22757500, compound

HRID 1704841Notes

Reaction equation

HRID 1704841 reaction equation
[CH3:1]C1C=CC(Br)=CC=1.BrC1C=CC=CC=1.C(N1N2C3C4C=NNC=4N=CC=3C(=O)N(C3C=CC=CC=3)C2=CC1C)C1OC=CC=1.CC1C=C2N(C3C=CC=CC=3)C(=O)C3C=NC4NN=CC=4C=3N2N=1.[C:70]([N:78]1[C:82]2[N:83]=[CH:84][C:85]3[C:86](=[O:101])[N:87]([C:95]4[CH:100]=[CH:99][CH:98]=[CH:97][CH:96]=4)[C:88]4[N:89]([N:91]=[C:92]([CH3:94])[CH:93]=4)[C:90]=3[C:81]=2[CH:80]=[N:79]1)(=[O:77])[C:71]1[CH:76]=[CH:75][CH:74]=[CH:73][CH:72]=1>>[C:70]([N:78]1[C:82]2[N:83]=[CH:84][C:85]3[C:86](=[O:101])[N:87]([C:95]4[CH:100]=[CH:99][C:98]([CH3:1])=[CH:97][CH:96]=4)[C:88]4[N:89]([N:91]=[C:92]([CH3:94])[CH:93]=4)[C:90]=3[C:81]=2[CH:80]=[N:79]1)(=[O:77])[C:71]1[CH:76]=[CH:75][CH:74]=[CH:73][CH:72]=1

Participants

6

Reactant 5

HCID 78054-BromotolueneHCID 7961BromobenzeneHCID 227574532-Methyl-4-phenyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-oneHCID 227574668-Benzoyl-2-methyl-4-phenyl-4H-pyrazolo[1,5-a]pyrazolo-[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-oneHCID 227574691-Furfuryl-2-methyl-4-phenyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one

Product 1

HCID 22757500HCID 22757500, compound

Procedure

By substituting p-methylphenyl bromide for the bromobenzene in the procedure of Example 21 (a), and proceeding as in parts (b) and (c), 8-benzoyl-2-methyl-4-(p-methylphenyl)-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one is obtained.

Sources & evidence

ORD record
ord-f47e46a5a51b4f2cba46045a569cf6cc
Source dataset
uspto-grants-1978_11
Patent number
US04127657

Reaction notes

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