Iodoethane → HCID 54033818, compound

HRID 1706328Notes

Reaction equation

HRID 1706328 reaction equation
[H-].[Na+].[CH3:3][C:4]1([CH3:16])[CH2:10][C:9](=[O:11])[NH:8][C@H:7]2[CH2:12][CH2:13][CH2:14][CH2:15][C@H:6]2[NH:5]1.[CH2:17](I)[CH3:18]>O1CCOCC1>[CH2:17]([N:8]1[C@H:7]2[CH2:12][CH2:13][CH2:14][CH2:15][C@H:6]2[NH:5][C:4]([CH3:16])([CH3:3])[CH2:10][C:9]1=[O:11])[CH3:18]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 24758Sodium hydrideHCID 53873380HCID 53873380, compound

Product 1

HCID 54033818HCID 54033818, compoundYield 98.5%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

1.25 g sodium hydride (50% in oil) was dissolved in p-dioxane in a 250 ml flask, and 4.15 g cis-4,4-dimethyl-decahydro-1,5-benzodiazepin-2-one added. The mixture is stirred for about 1.5 hr. and cooled. 5.0 g ethyl iodide dissolved in 5 ml dioxane was added and the mixture stirred at 55°-60° C. overnight. It is then cooled and the solvent is removed to yield 4.67 g of an oily product. The structure of the compound obtained is confirmed by IR, NMR and mass spectrometer data.

Workup

  1. temperatureand cooled
  2. additionwas added
  3. stirringthe mixture stirred at 55°-60° C. overnight
  4. temperatureIt is then cooled
  5. customthe solvent is removed

Sources & evidence

ORD record
ord-bcb61f648a894e8fa5dd45db9788dec6
Source dataset
uspto-grants-1980_06
Patent number
US04207228

Reaction notes

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