反应详情

A mixture of 4.7 g. of 3-fluoro-10-(1-methylethyl)imidazo[1,2-a:3,4-a']diquinolin-15-ium iodide, 20 ml. of dimethylformamide and 4.0 ml. of 4-methylpiperidine is stirred and heated at reflux for 1 hour, then evaporated at reduced pressure. The residue is stirred with 75 ml. of ethyl acetate and the resulting precipitate is collected by filtration. The solid is stirred with 150 ml. of 1% aqueous triethylamine hydroiodide, collected by filtration, washed with water and dried. This product is 10-(1-methylethyl-3-(4-methyl-1-piperidinyl)imidazo[1,2-a:3,4-a']diquinolin-15-ium iodide; m.p. 266°-269° C., after crystallization from methanol/acetonitrile.

1. additionA mixture of 4.7 g
2. temperatureheated
3. temperatureat reflux for 1 hour
4. customevaporated at reduced pressure
5. filtrationof ethyl acetate and the resulting precipitate is collected by filtration
6. stirringThe solid is stirred with 150 ml
7. filtrationof 1% aqueous triethylamine hydroiodide, collected by filtration
8. washwashed with water
9. customdried
10. customm.p. 266°-269° C., after crystallization from methanol/acetonitrile