Morpholine → HCID 20335569, compound

HRID 1706434Notes

Reaction equation

HRID 1706434 reaction equation
[I-:1].F[C:3]1[CH:12]=[CH:11][C:10]2[N:9]3[C:13]4[CH:22]=[CH:21][C:20]5[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=5[N+:14]=4[CH:23]=[C:8]3[CH:7]=[CH:6][C:5]=2[CH:4]=1.[NH:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>CN(C)C=O>[I-:1].[N:24]1([C:3]2[CH:12]=[CH:11][C:10]3[N:9]4[C:13]5[CH:22]=[CH:21][C:20]6[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=6[N+:14]=5[CH:23]=[C:8]4[CH:7]=[CH:6][C:5]=3[CH:4]=2)[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 20335504HCID 20335504, compound

Product 1

HCID 20335569HCID 20335569, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 1.04 g. of 10-fluoroimidazo[1,2-a:3,4-a']diquinolin-15-ium iodide, 3.0 ml. of morpholine and 40 ml. of dimethylformamide is heated at gentle reflux for 40 hours, treated with 1.5 g. of sodium iodide and evaporated at reduced pressure to give 10-(4-morpholinyl)imidazo[1,2-a:3,4-a']diquinolin-15-ium iodide; m.p. >300° C. after two crystallizations from aqueous methanol.

Workup

  1. additionA mixture of 1.04 g
  2. temperatureat gentle reflux for 40 hours
  3. additiontreated with 1.5 g
  4. customof sodium iodide and evaporated at reduced pressure

Sources & evidence

ORD record
ord-2db63b528f0f47f7bed454c25fa9f69c
Source dataset
uspto-grants-1980_06
Patent number
US04207320

Reaction notes

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