反应详情

A mixture of 4.41 g. of 3,10-difluoroimidazo[1,2-a:3,4-a']diquinolin-15-ium iodide, 9.0 ml. of pyrrolidine and 130 ml. of N-methyl-2-pyrrolidinone is stirred and heated at 130°-160° C. for 4.5 hours, then cooled. The resulting precipitate is collected, washed with methanol and stirred with 100 ml. of 2% aqueous triethylamine hydroiodide for 1 hour. The resulting precipitate of 3,10-di-(1-pyrrolidinyl)imidazo[1,2-a:3,4-a']diquinolin-15-ium iodide is collected by filtration, washed with water and dried; m.p. 345° C. (dec.), after crystallization from dimethylformamide/-2-propanol.

1. additionA mixture of 4.41 g
2. temperatureheated at 130°-160° C. for 4.5 hours
3. temperaturecooled
4. customThe resulting precipitate is collected
5. washwashed with methanol
6. filtrationThe resulting precipitate of 3,10-di-(1-pyrrolidinyl)imidazo[1,2-a:3,4-a']diquinolin-15-ium iodide is collected by filtration
7. washwashed with water
8. customdried
9. customm.p. 345° C. (dec.), after crystallization from dimethylformamide/-2-propanol