Sodium Iodide → HCID 12463847, compound

HRID 1706700Notes

Reaction equation

HRID 1706700 reaction equation
[CH3:1][O:2][C:3]1[CH:17]=[CH:16][C:6]([CH2:7][CH:8]2[CH2:13][CH2:12][CH:11]([CH2:14]Br)[CH2:10][CH2:9]2)=[CH:5][CH:4]=1.[I-:18].[Na+]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:17]=[CH:16][C:6]([CH2:7][CH:8]2[CH2:13][CH2:12][CH:11]([CH2:14][I:18])[CH2:10][CH2:9]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 12463846HCID 12463846, compound

Product 1

HCID 12463847HCID 12463847, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 17.5 g. (0.065 m) of 4-(4-methoxybenzyl)-cyclohexylmethyl bromide, 11 g. (0.073 m) of sodium iodide and 100 ml. of acetone was heated under reflux for two hours. The solvent was removed, the residue partitioned between water and ether, and the ether layer dried and concentrated to give 19.8 g. of oil, used directly in the next reaction.

Workup

  1. additionA mixture of 17.5 g
  2. temperatureunder reflux for two hours
  3. customThe solvent was removed
  4. customthe residue partitioned between water and ether
  5. dry with materialthe ether layer dried
  6. concentrationconcentrated
  7. customto give 19.8 g
  8. customof oil, used directly in the next reaction

Sources & evidence

ORD record
ord-bf58cf1df3af4fc7bc9a9c5c2543c380
Source dataset
uspto-grants-1980_06
Patent number
US04208425

Reaction notes

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