Morpholine → Piperidine

HRID 1706966Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5]O[CH2:3][CH2:2]1.COC(C1N=C(CN2CCCC2)[N:13]([C:22]2[CH:27]=[CH:26][C:25](Cl)=[CH:24]C=2C(=O)C2C=CC=CC=2)N=1)=O.COC(C1N=C(CN2CCCCC2)N(C2C=CC(Cl)=CC=2C(=O)C2C=CC=CC=2)N=1)=O>>[NH:1]1[CH2:6][CH2:5][CH2:3][CH2:2]1.[NH:13]1[CH2:22][CH2:27][CH2:26][CH2:25][CH2:24]1

Participants

Reactant 3

HCID 8083Morpholine

HCID 54024720HCID 54024720, compound

HCID 54560355HCID 54560355, compound

Product 2

HCID 8082Piperidine

HCID 31268Pyrrolidine

Procedure

By a procedure analogous to that of Example 1 there are obtained, with the use of 2.9 g (0.041 mole) of pyrrolidine and 3.0 g (0.041 mole) of piperidine, instead of morpholine, crude 1-(2-benzoyl-4-chlorophenyl)-5-[(1-pyrrolidinyl)-methyl]-1H-1,2,4-triazole-3-carboxylic acid methyl ester and crude 1-(2-benzoyl-4-chlorophenyl)-5-(piperidinomethyl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester, respectively.

Sources & evidence

ORD record: ord-9af581652b2f4c738d13ab306bcee21f
Source dataset: uspto-grants-1980_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04209515

Reaction notes

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