4'-Fluoroacetophenone → 3-(Dimethylamino)-1-(4-fluorophenyl)prop-2-en-1-one

HRID 1707054Notes

Reaction equation

HRID 1707054 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.CO[CH:13](OC)[N:14]([CH3:16])[CH3:15]>>[CH3:13][N:14]([CH3:16])[CH:15]=[CH:9][C:8]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)=[O:10]

Participants

3

Reactant 2

HCID 98284'-FluoroacetophenoneHCID 78373Dimethylformamide dimethyl acetal

Product 1

HCID 6005393-(Dimethylamino)-1-(4-fluorophenyl)prop-2-en-1-one

Procedure

A mixture of 5.0 g. of p-fluoroacetophenone and 10 ml. of dimethylformamide dimethylacetal is refluxed for 4 hours. Evaporation gives an oil which crystallizes with the addition of hexane to give the product, m.p. 83.5°-84° C.

Workup

  1. additionA mixture of 5.0 g
  2. customEvaporation
  3. customgives an oil which
  4. customcrystallizes with the addition of hexane
  5. customto give the product, m.p. 83.5°-84° C.

Sources & evidence

ORD record
ord-1df479f2c3e64a28b5806bf1484dfbe1
Source dataset
uspto-grants-1980_06
Patent number
US04209621

Reaction notes

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