Water → Trifluoromethyl toluidine

HRID 1707167Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1707167
O.[NH2:2][C:3]1[C:4]([CH2:14]SC)=[C:5]([C:10]([F:13])([F:12])[F:11])[CH:6]=[CH:7][C:8]=1Cl>C(O)(=O)C>[NH2:2][C:3]1[C:4]([CH3:14])=[C:5]([C:10]([F:11])([F:12])[F:13])[CH:6]=[CH:7][CH:8]=1

Komponenten

4

Edukt 2

HCID 962WaterHCID 233529853-Amino-4-chloro-2-methylthiomethylbenzotrifluoride

Produkt 1

HCID 2735932Trifluoromethyl toluidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Add 70 ml of water, 150 ml of glacial acetic acid and 100 g. of 3-amino-4-chloro-2-methylthiomethylbenzotrifluoride to a three-necked round bottom flask fitted with mechanical stirrer and condenser. Then add 535 g. of washed and neutralized Raney active nickel catalyst (Grace no. 28 in water). Heat to reflux (98° C.-100° C.) for 20 hours. Steam distill to obtain the title compound.

Aufarbeitung

  1. additionThen add 535 g
  2. washof washed
  3. temperatureHeat
  4. temperatureto reflux (98° C.-100° C.) for 20 hours
  5. distillationSteam distill

Quellen und Nachweise

ORD-Eintrag
ord-a5e3a695aa3142dd85029d9271c76a7f
Quelldatensatz
uspto-grants-1980_06
Patentnummer
US04209464

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