3-Hydroxybenzoic Acid → HCID 178420621, compound

HRID 1707217Notes

Reaction equation

HRID 1707217 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11]([OH:13])=[O:12]>C(O)C>[OH:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11]([O-:13])=[O:12].[NH2+:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 74203-Hydroxybenzoic AcidHCID 8082Piperidine

Product 1

HCID 178420621HCID 178420621, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Piperidine (0.85 g; 10 mmol) was added dropwise to a solution of 3-hydroxybenzoic acid (1.38 g; 10 mmol) in ethanol (10 cm3). The solution was then left to stand at 5° C. in an open beaker for two weeks. This produced the desired product in the form of white crystals. The product was collected by filtration and recrystallized from water to produce translucent, colourless crystals. Found: C, 63.4%; H, 7.6%; N, 6.2%. Calculated for C12H17NO3 ; C, 64.55%; H, 7.69%; N, 6.24%. M.pt. 154°-156° C.

Workup

  1. waitThe solution was then left
  2. waitto stand at 5° C. in an open beaker for two weeks

Sources & evidence

ORD record
ord-6f0b234dc59d45e28e6d4a98685ae6c7
Source dataset
uspto-grants-1994_10
Patent number
US05352388

Reaction notes

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