Veratrole → HCID 18963080, Verbindung

HRID 1707297Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1707297
[Cl-].[Al+3].[Cl-].[Cl-].[Cl-].CO[C:8](=[O:15])[CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13].[C:16]1([O:24]C)[C:17](=[CH:20][CH:21]=[CH:22][CH:23]=1)[O:18]C.Cl.N1C=CC=CC=1>ClCCl>[OH:18][C:17]1[CH:20]=[C:21]([C:8](=[O:15])[CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])[CH:22]=[CH:23][C:16]=1[OH:24]

Komponenten

6

Edukt 4

HCID 7043VeratroleHCID 6451240Aluminum(III) ChlorideHCID 10176127Pyridinium chlorideHCID 53445129Glutaric acid monomethylester chloride

Produkt 1

HCID 18963080HCID 18963080, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Under the conditions of example 3A, 28.8g of aluminum chloride in 320 ml of dichloromethane is reacted with 11.9g of glutaric acid monomethyl ester chloride and 10g of veratrole, worked up and chromatographed. The thus obtained crude product is further reacted under the conditions of example 3A with 270g of pyridinehydrochloride and worked up. 5.6g of 5-(3,4-dihydroxyphenyl)- 5-oxo-pentanoic acid of melting point 210°-215° C. is obtained as crude product.

Aufarbeitung

  1. customchromatographed
  2. customThe thus obtained crude product

Quellen und Nachweise

ORD-Eintrag
ord-c587a82bc9e0421182056b52153bcac5
Quelldatensatz
uspto-grants-1994_10
Patentnummer
US05352701

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