4-Chlorophenyl Isocyanate → HCID 18961891, compound

HRID 1707590Notes

Reaction equation

HRID 1707590 reaction equation
[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]1[S:13][CH2:14][CH3:15].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]=[C:24]=[O:25])=[CH:19][CH:18]=1>ClCCCl>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([NH:23][C:24]([NH:1][N:2]2[C:11](=[O:12])[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[N:4]=[C:3]2[S:13][CH2:14][CH3:15])=[O:25])=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 76934-Chlorophenyl IsocyanateHCID 112760734(3H)-Quinazolinone, 3-amino-2-(ethylthio)-

Product 1

HCID 18961891HCID 18961891, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Conditions

Temperature
0 °C

Procedure

A mixture of 3-amino-2-ethylthio-4-quinazolone (0.60 g, 2.71 mmol) and 4-chlorophenyl isocyanate (0.48 g, 3.13 mmol) in 1,2-dichloroethane is heated at reflux for 63 hours, cooled to 0° C. and filtered. The filter cake is washed with ether and dried to give the title product as a white solid, 0.84 g (83%) mp 234°-235° C.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 63 hours
  3. filtrationfiltered
  4. washThe filter cake is washed with ether
  5. customdried

Sources & evidence

ORD record
ord-335ff15df13f40408bcda5a7315dd52b
Source dataset
uspto-grants-1994_10
Patent number
US05354755

Reaction notes

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