HCID 15224908, compound → HCID 131718729, compound

HRID 1707626Notes

Reaction equation

HRID 1707626 reaction equation
[Cl:1][C:2]1[CH:27]=[CH:26][C:5]2[O:6][C:7]3[CH:25]=[CH:24][CH:23]=[CH:22][C:8]=3[CH2:9][N:10]([C:11]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH3:21])[CH2:15][CH2:14]3)=[O:12])[C:4]=2[CH:3]=1>Cl.CO>[ClH:1].[Cl:1][C:2]1[CH:27]=[CH:26][C:5]2[O:6][C:7]3[CH:25]=[CH:24][CH:23]=[CH:22][C:8]=3[CH2:9][N:10]([C:11]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH3:21])[CH2:15][CH2:14]3)=[O:12])[C:4]=2[CH:3]=1

Participants

4

Reactant 1

HCID 15224908HCID 15224908, compound

Product 1

HCID 131718729HCID 131718729, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

The title compound was synthesized from the title material of Example 16 (1.11 g, 2.9 mmol) by dissolving it in 28 mL of 2N HCl in methanol (MeOH). After stirring this solution for 30 minutes, all solvent was removed under reduced pressure. The resulting residue was washed with Et2O, dissolved in water, treated with activated charcoal, filtered and lyophilized. An 0.80 g sample of the pale green solid title product was obtained.

Workup

  1. customall solvent was removed under reduced pressure
  2. washThe resulting residue was washed with Et2O
  3. dissolutiondissolved in water
  4. additiontreated with activated charcoal
  5. filtrationfiltered

Sources & evidence

ORD record
ord-40293d7778ff4b37a119ef424a94fa03
Source dataset
uspto-grants-1994_10
Patent number
US05354747

Reaction notes

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