Hydrochloric Acid → 39640-04-5

HRID 1707631Notes

Reaction equation

HRID 1707631 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([N:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)=[O:8])=[CH:3][CH:2]=1.Cl.C([O-])([O-])=O.[K+].[K+]>C(Cl)Cl>[N:1]1[CH:6]=[CH:5][C:4]([C:7]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[O:8])=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 15289251HCID 15289251, compound

Product 1

HCID 87655339640-04-5

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title material was synthesized from the title product of Example 26 (1.3 g, 4.46 mmol) by the method described in Example 25, except that the title free base was generated by treatment of its HCl salt with 0.5N K2CO3 in CH2Cl2. The CH2Cl2 solution was dried over Na2SO4 and all solvent removed under reduced pressure to provide 333 mg of the title free base. This material was used without further purification.

Workup

  1. dry with materialThe CH2Cl2 solution was dried over Na2SO4
  2. customall solvent removed under reduced pressure
  3. customto provide 333 mg of the title free base
  4. customThis material was used without further purification

Sources & evidence

ORD record
ord-8f1c74933a8048a0a466d1baba5ba83c
Source dataset
uspto-grants-1994_10
Patent number
US05354747

Reaction notes

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