Hydrochloric Acid → HCID 18962694, compound

HRID 1707824Notes

Reaction equation

HRID 1707824 reaction equation
[CH3:1][C:2]([C:4]([CH2:7][CH3:8])([CH3:6])[CH3:5])=[O:3].[CH:9]#[CH:10].Cl>O1CCCC1>[CH3:1][C:2]([OH:3])([C:4]([CH3:6])([CH3:5])[CH2:7][CH3:8])[C:9]#[CH:10]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6326AcetyleneHCID 1407383,3-Dimethyl-2-pentanone

Product 1

HCID 18962694HCID 18962694, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

50 g of tert-amyl methyl ketone were dissolved in 50 ml of tetrahydrofuran and the solution was added dropwise at 0° C. to 330 ml of a 1.5 molar acetylene Grignard solution in tetrahydrofuran. After 30 min, the mixture was hydrolyzed with 2N hydrochloric acid, the organic phase was separated, the solvent was removed and the residue was then fractionally distilled. 52 g (85%) of 3,4,4-trimethylhex-1-yn-3-ol were obtained (b.p.: 110° C./175 mbar).

Workup

  1. customthe organic phase was separated
  2. customthe solvent was removed
  3. distillationthe residue was then fractionally distilled

Sources & evidence

ORD record
ord-0f9ae622ed0e43b99c722b701806b631
Source dataset
uspto-grants-1994_10
Patent number
US05354937

Reaction notes

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