Pyridine → HCID 15046665, compound

HRID 1707970Notes

Reaction equation

HRID 1707970 reaction equation
[OH:1][C@@H:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]#[CH:9])[C:3]1=[O:10].[C:11](OC(=O)C)(=[O:13])[CH3:12].N1C=CC=CC=1>CN(C)C1C=CN=CC=1.C(Cl)Cl>[C:11]([O:1][C@@H:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]#[CH:9])[C:3]1=[O:10])(=[O:13])[CH3:12]

Participants

6

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 15046659HCID 15046659, compound

Product 1

HCID 15046665HCID 15046665, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

The title compound is prepared by the procedure of Example 52 using 19.6 g of (R)-3-hydroxy-1-(2-propynyl)-2-pyrrolidinone, 26.6 ml of acetic anhydride, 17 ml of pyridine, 0.6 g of 4-(dimethylamino)pyridine and 200 ml of methylene chloride to give 23.4 g of the desired product as a pale yellow oil. [α]D26° =+59° (methylene chloride).

Sources & evidence

ORD record
ord-ec4401534edf423da94406a1748e59a8
Source dataset
uspto-grants-1994_10
Patent number
US05356885

Reaction notes

Loading…