Potassium Carbonate → HCID 785841, compound

HRID 1708063Notes

Reaction equation

HRID 1708063 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]Br)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[NH:16]1[CH2:21][CH2:20][S:19][CH2:18][CH2:17]1>C1COCC1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:16]2[CH2:21][CH2:20][S:19][CH2:18][CH2:17]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 67164ThiomorpholineHCID 685274-Bromobenzyl bromide

Product 1

HCID 785841HCID 785841, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 1-bromo-4-(bromomethyl)benzene (760 mg) in dry THF (10 ml) containing potassium carbonate (386 mg) was treated dropwise with thiomorpholine (0.36 ml, 369 mg). The resulting mixture was stirred at room temperature under nitrogen for 20 h before filtering and concentrating in vacuo to give impure title compound which was purified by FCC eluting with dichloromethane to give the title compound as a crystalline white solid (634 mg). m.p. 74°-75° C.

Workup

  1. filtrationbefore filtering
  2. concentrationconcentrating in vacuo

Sources & evidence

ORD record
ord-90913318418a4306a6b071aa12734a5b
Source dataset
uspto-grants-1994_10
Patent number
US05356893

Reaction notes

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