Hydrochloric Acid → HCID 18961239, compound

HRID 1708224Notes

Reaction equation

HRID 1708224 reaction equation
C1(=O)[N:5]([CH2:6][CH:7]([CH2:20][CH3:21])[CH2:8][N:9]2C(=O)C3=CC=CC=C3C2=O)C(=O)C2=CC=CC=C12.[ClH:28]>C(O)C>[ClH:28].[ClH:28].[CH2:20]([CH:7]([CH2:8][NH2:9])[CH2:6][NH2:5])[CH3:21]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18961238HCID 18961238, compound

Product 1

HCID 18961239HCID 18961239, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture consisting of 1,3-diphthalimido-2-ethylpropane (25 g, 69 mmol) concentrated hydrochloric acid (700 mL), and ethanol (700 mL) was refluxed for 6 days with additional concentrated hydrochloric acid being added at the indicated time; 3 days (300 mL), 4 days (200 mL), 5 days (200 mL). The reaction was evaporated to dryness and the residue was diluted with water (200 mL), chilled, and filtered. The filtrate was washed with ethyl acetate (5×500 mL) and evaporated to leave 12 g (100%) of 2-ethyl-1,3-propanediamine dihydrochloride as a thick oil.

Workup

  1. additionadded at the indicated time
  2. custom3 days (300 mL), 4 days (200 mL), 5 days (200 mL)
  3. customThe reaction was evaporated to dryness
  4. additionthe residue was diluted with water (200 mL)
  5. temperaturechilled
  6. filtrationfiltered
  7. washThe filtrate was washed with ethyl acetate (5×500 mL)
  8. customevaporated

Sources & evidence

ORD record
ord-ecf88283a288499b95d24e6c64f7bc85
Source dataset
uspto-grants-1994_10
Patent number
US05356932

Reaction notes

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