反应详情

A mixture of 1.00 g of 1,2,3,4-tetrahydroisoquinoline, 0.042 g of selenium dioxide, 2.30 ml of 30% hydrogen peroxide in 20 ml of methanol is stirred at room temperature for 20 hours. The reaction mixture is concentrated in vacuo to a residue which is diluted with water and extracted with chloroform. The organic layer is dried and evaporated in vacuo to a residue which is purified by column chromatography on silica gel by elution with 99:1 methanol-chloroform to give 0.703 g of the desired product as a solid.

1. concentrationThe reaction mixture is concentrated in vacuo to a residue which
2. additionis diluted with water
3. extractionextracted with chloroform
4. customThe organic layer is dried
5. customevaporated in vacuo to a residue which
6. customis purified by column chromatography on silica gel by elution with 99:1 methanol-chloroform