Sodium hydride → HCID 131718754, compound

HRID 1708511Notes

Reaction equation

[H-].[Na+].[Br:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[SH:10].[H][H].[Si:13](Cl)([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14]>C1COCC1>[Br:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14]

Participants

Conditions

Temperature: 0 °C

Procedure

A dry 500 ml round bottom flask, equipped with a magnetic stirring bar and maintained under static argon atmosphere, was charged with sodium hydride (4.55 g, 113 mmol) in mineral oil (60% by weight) and dry THF (80 ml). To this well-stirred slurry, maintained at 0° C. in an ice bath, was added o-bromothiophenol (18.7 g, 99 mmol). Reaction was rapid with vigorous hydrogen evolution. After 15 min, tert-butyldimethylsilyl chloride dissolved in 35 ml of THF was added dropwise (15 min). The resulting mixture was stirred overnight, and the precipitated sodium chloride was filtered off. Volatile materials were first distilled under atmospheric pressure to provide the crude product (17 g) as a pale yellow oil. This was further purified by vacuum distillation under argon, bp 99°-100° C. (0.4 mm), to furnish o-bromo-(S-tert-butyldimethylsilyl)benzenethiol as a colorless liquid (14.4 g, 48% yield); HPLC: 96% pure. 1H NMR (300 MHz) was consistent with the structure:

Workup

customA dry 500 ml round bottom flask, equipped with a magnetic stirring bar
temperaturemaintained under static argon atmosphere
customReaction
additionwas added dropwise (15 min)
filtrationthe precipitated sodium chloride was filtered off
distillationVolatile materials were first distilled under atmospheric pressure
customto provide the crude product (17 g) as a pale yellow oil
distillationThis was further purified by vacuum distillation under argon

Sources & evidence

ORD record: ord-3abd934154c34d7d8765623fd8277b2d
Source dataset: uspto-grants-1994_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05359065

Reaction notes

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