Pyrazole → HCID 178522630, compound

HRID 1708850Notes

Reaction equation

HRID 1708850 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[N:10]1[C:14](=[O:15])[CH:13](Br)[C:12]([NH:17][C:18](=[O:28])[C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([N+:25]([O-:27])=[O:26])[CH:20]=2)=[N:11]1.[NH:29]1[CH:33]=[CH:32][CH:31]=[N:30]1>C(#N)C>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[N:10]1[C:14](=[O:15])[CH:13]([C:33]2[CH:32]=[CH:31][NH:30][N:29]=2)[C:12]([NH:17][C:18](=[O:28])[C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([N+:25]([O-:27])=[O:26])[CH:20]=2)=[N:11]1

Participants

4

Reactant 2

HCID 1048PyrazoleHCID 23037982HCID 23037982, compound

Product 1

HCID 178522630HCID 178522630, compoundYield 66.5%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Next, 304 g (0.6 mol) of the 1-(2,4,6-trichlorophenyl)-3-(3-nitrobenzamido)-4-bromo-5-oxo-2pyrazoline and 163 g (2.4 mol) of pyrazole were mixed well and then heated to react for about 5 to 6 hours at 80° to 90° C in a stream of nitrogen gas. The mixture was then cooled to room temperature, 700 ml of acetonitrile was added, and the deposited crystals were thereafter filtered to obtain 197 g (66 %) of 1-(2,4,6-trichlorophenyl)-3-(3-nitrobenzamido)-4-pyrazolyl-5-oxo-2-pyrazoline.

Workup

  1. temperatureheated
  2. customto react for about 5 to 6 hours at 80° to 90° C in a stream of nitrogen gas
  3. filtrationthe deposited crystals were thereafter filtered

Sources & evidence

ORD record
ord-1064dbd6c4c64b79b9e2867add392723
Source dataset
uspto-grants-1990_08
Patent number
US04946771

Reaction notes

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