HRID1709066

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6212

Chloroform

CHCl3

HCID10935

Maleimide

C4H3NO2

2 次

结构：CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)OCC(O)CO)OC(=O)CCCCCCCC=CCCCCCCCC

HCID119120

3-{[(2,3-Dihydroxypropoxy)(hydroxy)phosphoryl]oxy}-2-[(octadec-9-enoyl)oxy]propyl octadec-9-enoate

C42H79O10P

$结构：CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC$

HCID10350317

1,2-Dioleoyl-sn-glycero-3-phosphocholine

C44H84NO8P

$结构：CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC.CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)OCC(O)CO)OC(=O)CCCCCCCC=CCCCCCCCC$

HCID131716291

Dopg dopc

C86H163NO18P2

PRODUCTS

生成物

$结构：CCCCCCCC/C=C\CCCCCCCCOCC(C[N+](C)(C)C)OCCCCCCCC/C=C\CCCCCCCC.[Cl-]$

HCID6438350

未命名化合物

PROCEDURE

实验过程

DOPG/DOPC sonicated vesicles containing maleimide-PE were prepared by dissolving 16 mg DOPG, 24 mg DOPC and 0.4 mg maleimide-PE in chloroform and removing the solvent by drying under a stream of nitrogen gas. This dried film was placed under vacuum overnight to remove traces of solvent. The film was then suspended in 0.8 ml water with vigorous shaking and sonicated in a bath type sonicator for 30 minutes until clear producing DOTMA/DOPPC SUV's at a concentration of 50 mg/ml.

WORKUP

后处理

customwere prepared
customremoving the solvent
customby drying under a stream of nitrogen gas
customwas placed under vacuum overnight
customto remove traces of solvent
customsonicated in a bath type sonicator for 30 minutes

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c3ec95f0568040cdacff9f366921d38a
来源数据集: uspto-grants-1990_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04946787
来源说明: uspto-grants-1990_08

反应 SMILES

[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]=[CH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O:20][CH2:21][CH:22]([O:34][C:35]([CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH:44]=[CH:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH3:53])=O)[CH2:23]OP(OCC(O)CO)(O)=O)=O.CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COP(OC[CH2:83][N+:84](C)([CH3:86])[CH3:85])([O-])=O)=O.C1(=O)NC(=O)C=C1.CCCCCCCCC=CCCCCCCCC(OCC(OC(CCCCCCCC=CCCCCCCCC)=O)COP(OCC(O)CO)(O)=O)=O.CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O.C(Cl)(Cl)[Cl:223]>>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][O:20][CH2:21][CH:22]([O:34][CH2:35][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43]/[CH:44]=[CH:45]\[CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH3:53])[CH2:23][N+:84]([CH3:86])([CH3:85])[CH3:83].[Cl-:223]