反应详情

A mixture of 2.5 g of 5-hydroxy-pyrrolidin-2-one and 1.25 g of Amberlite IR 120 H is agitated at 65° C. for 3 hours in 55 cm3 of n-pentanol. After cooling to ambient temperature, filtering, and distilling under reduced pressure, the residue is chromatographed on silica (eluent: ethyl acetate), and 2.68 g of the expected product is obtained. m.p. 42°-43° C.

1. filtrationfiltering
2. distillationdistilling under reduced pressure
3. customthe residue is chromatographed on silica (eluent: ethyl acetate)