Hydrochloric Acid → HCID 14835764, compound

HRID 1709256Notes

Reaction equation

HRID 1709256 reaction equation
[C:1]1(/[CH:7]=[CH:8]/[CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH:16]3[C:26]4[C:21](=[N:22][CH:23]=[CH:24][CH:25]=4)[CH2:20][CH2:19][C:18]4[CH:27]=[CH:28][CH:29]=[CH:30][C:17]3=4)[CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O1CCOCC1.[ClH:37]>C(O)(C)C>[ClH:37].[ClH:37].[ClH:37].[C:1]1(/[CH:7]=[CH:8]/[CH2:9][N:10]2[CH2:11][CH2:12][N:13]([CH:16]3[C:26]4[C:21](=[N:22][CH:23]=[CH:24][CH:25]=4)[CH2:20][CH2:19][C:18]4[CH:27]=[CH:28][CH:29]=[CH:30][C:17]3=4)[CH2:14][CH2:15]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 14835763HCID 14835763, compound

Product 1

HCID 14835764HCID 14835764, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

1.58 g of the 5-[4-{(E)-3-phenylallyl}-piperazin-1-yl]-10,11-dihydro-5H-benzo[4,5]cyclohepta-[1,2-b]pyridine was dissolved in 24 ml of isopropyl alcohol. To the solution was dropwise added 8 ml of a 2N dioxane solution of hydrogen chloride at room temperature. After the completion of the addition, the resulting mixture was stirred for 1 hour at the same temperature. The resulting crystals were collected by filtration to obtain 1.90 g of 5-[4-{(E)-3-phenylallyl}piperazin-1-yl]-10,11-dihydro-5H-benzo-[4,5]cyclohepta[1,2-b]pyridine trihydrochloride having a melting point of 174°-176° C.

Workup

  1. customat room temperature
  2. additionAfter the completion of the addition
  3. filtrationThe resulting crystals were collected by filtration

Sources & evidence

ORD record
ord-06cc317f6a6d4958b14458e5e510f632
Source dataset
uspto-grants-1990_08
Patent number
US04948796

Reaction notes

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