4-Aminopyridine → HCID 14819972, compound

HRID 1709633Notes

Reaction equation

HRID 1709633 reaction equation
[Cl:1][CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[NH:12][C:13]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=1)=[O:4].CC1C=CC(NC2C(N)=CC=CC=2)=CC=1.[NH2:35][C:36]1[CH:41]=[CH:40][N:39]=[CH:38][CH:37]=1>C(Cl)(Cl)Cl>[ClH:1].[CH3:19][C:16]1[CH:17]=[CH:18][C:13]([NH:12][C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[NH:5][C:3](=[O:4])[CH2:2][NH:35][C:36]2[CH:41]=[CH:40][N:39]=[CH:38][CH:37]=2)=[CH:14][CH:15]=1

Participants

5

Reactant 3

HCID 17274-AminopyridineHCID 233165691806-09-6HCID 14819970HCID 14819970, compound

Product 1

HCID 14819972HCID 14819972, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

2-Chloro-N-[2-[(4-methylphenyl)amino]phenyl]acetamide which had been synthesized from N-(4-methylphenyl)-1,2-benzenediamine by substantially the same manner as described in Reference Example 1 and 4-aminopyridine were dissolved in chloroform and the solution was left on standing under stirring at room temperature overnight, whereby the reaction was completed. The resulting precipitates were collected by filtration and recrystallized from ethanol to give N-[2-[(4-methylphenyl)amino]phenyl]-2-[(4-pyridinyl)amino]-acetamide hydrochloride.

Workup

  1. waitthe solution was left
  2. customThe resulting precipitates
  3. filtrationwere collected by filtration
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-d7aecc1840894ac48135a4e1696aa87f
Source dataset
uspto-grants-1990_08
Patent number
US04950667

Reaction notes

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