Hydrochloric Acid → HCID 70374049, compound

HRID 1709793Notes

Reaction equation

HRID 1709793 reaction equation
[Cl:1][CH2:2][CH:3]1[CH:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[O:6][N:5]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([O:22]CC)=[O:21])=[CH:16][C:15]=2[N+:25]([O-:27])=[O:26])[C:4]1=[O:28].O1CCOCC1.Cl>O>[Cl:1][CH2:2][CH:3]1[CH:7]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[O:6][N:5]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([OH:22])=[O:21])=[CH:16][C:15]=2[N+:25]([O-:27])=[O:26])[C:4]1=[O:28]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 70374119HCID 70374119, compound

Product 1

HCID 70374049HCID 70374049, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

270 g (0.67 mols.) of 4-chloromethyl-5-phenyl-2-(4-ethoxycarbonyl-2-nitrophenyl)isoxazolin-3-one was added to 2.5 liters of 1,4-dioxane, and 300 ml of concentrated hydrochloric acid was added thereto, followed by refluxing the mixture for 8 hours under heating. After cooling, water was added to the reaction solution, and the crystals which precipitated were collected by filtration, washed with water, and dried.

Workup

  1. additionwas added
  2. temperatureby refluxing the mixture for 8 hours
  3. temperatureunder heating
  4. temperatureAfter cooling
  5. customthe crystals which precipitated
  6. filtrationwere collected by filtration
  7. washwashed with water
  8. customdried

Sources & evidence

ORD record
ord-7e0a02dcca494789be576d110c8f564b
Source dataset
uspto-grants-1990_08
Patent number
US04950764

Reaction notes

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