P-Cresol → 2-(alpha-Methylbenzyl)-p-cresol

HRID 1709803Notes

Reaction equation

[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[C:3]([CH3:8])[CH:2]=1.[PH2](O)=O.ClC(C)C(O)=O.[CH2:18]=[CH:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH3:18][CH:19]([C:1]1[CH:2]=[C:3]([CH3:8])[CH:4]=[CH:5][C:6]=1[OH:7])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

Reactant 4

HCID 2879P-Cresol

HCID 7501Styrene

HCID 117342-Chloropropionic acid

HCID 4124402Phosphinic Acid

Product 1

HCID 953232-(alpha-Methylbenzyl)-p-cresol

Procedure

The reaction was similarly carried out as Example 10 except that into a mixture of 32 g of p-cresol, 4 g of hypophosphorous acid and 6 g of α-chloropropionic acid was poured 36 g of styrene to give only 2-(α-methylbenzyl)-4-methylphenol, but not to detect other tert-butylated compounds.

Sources & evidence

ORD record: ord-3ed9333fe59744c8b4662188fdef8e88
Source dataset: uspto-grants-1990_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04950810

Reaction notes

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