反应详情

A mixture of 10.6 g (0.637 mole) of 1-(4-hydroxy-2-methoxyphenyl)ethanone, 20 g (0.127 mole) of 1-bromo-3-chloropropane and 26.4 g (0.19 mole) of anhydrous potassium carbonate in 250 ml of acetone was heated at reflux for 20 hr. The mixture was cooled, filtered and the filtrate concentrated under vacuum pump pressure at 90° C. to give an oil which gradually crystallized. The solid was triturated with petroleum ether (30°-60° C.), collected by filtration and dried to yield 14.6 g (94%) of white solid, m.p. 47°-49° C. on recrystallizing from isopropyl ether.

1. temperaturewas heated
2. temperatureat reflux for 20 hr
3. temperatureThe mixture was cooled
4. filtrationfiltered
5. concentrationthe filtrate concentrated under vacuum pump pressure at 90° C.
6. customto give an oil which
7. customgradually crystallized
8. customThe solid was triturated with petroleum ether (30°-60° C.)
9. filtrationcollected by filtration
10. customdried