反应详情

A mixture of 6.6 g (0.036 mole) of (4-hydroxyphenyl)carbamic acid ethyl ester, 11.5 g (0.072 mole) of 1-bromo-3-chloropropane, 13.8 g (0.10 mole) of anhydrous potassium carbonate and 150 ml of acetone was heated at reflux for 21 hr. The mixture was cooled and filtered. The filtrate was concentrated under reduced pressure to give a solid residue. The solid was triturated with petroleum ether (30°-60° C.) collected by filtration and recrystallized from isopropanol to yield 7.7 g (83%) of white solid, m.p. 91°-93° C.

1. temperaturewas heated
2. temperatureat reflux for 21 hr
3. temperatureThe mixture was cooled
4. filtrationfiltered
5. concentrationThe filtrate was concentrated under reduced pressure
6. customto give a solid residue
7. customThe solid was triturated with petroleum ether (30°-60° C.)
8. filtrationcollected by filtration
9. customrecrystallized from isopropanol