Potassium Iodide → HCID 44271485, compound

HRID 1709917Notes

Reaction equation

HRID 1709917 reaction equation
C(O)(=O)C(O)=O.C1(C(C2C=CC=CC=2)=C2CCN(CCCOC3C=CC=CC=3)CC2)C=CC=CC=1.[C:36]1([C:42]([C:50]2[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=2)([CH:44]2[CH2:49][CH2:48][NH:47][CH2:46][CH2:45]2)[OH:43])[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1.[CH3:56][O:57][C:58](=[O:70])[C:59]1[CH:64]=[CH:63][C:62]([O:65][CH2:66][CH2:67][CH2:68]Cl)=[CH:61][CH:60]=1.C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+]>CN(C)C=O>[CH3:56][O:57][C:58](=[O:70])[C:59]1[CH:64]=[CH:63][C:62]([O:65][CH2:66][CH2:67][CH2:68][N:47]2[CH2:48][CH2:49][CH:44]([C:42]([OH:43])([C:50]3[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=3)[C:36]3[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=3)[CH2:45][CH2:46]2)=[CH:61][CH:60]=1

Participants

7

Reactant 5

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 15723AzacyclonolHCID 12389265Methyl 4-(3-chloropropoxy)benzoateHCID 230363354-(Diphenylmethylene)-1-(3-phenoxypropyl)piperidine oxalate

Product 1

HCID 44271485HCID 44271485, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This compound was prepared according to the procedure used to synthesize the compound of Example 1. A mixture of 5.3 g (0.02 mole) of α,α-diphenyl-4-piperidinemethanol, 4.6 g (0.02 mole) of 4-(3-chloropropoxy)benzoic acid methyl ester, 7.4 g (0.07 mole) of anhydrous sodium carbonate and 0.5 g of potassium iodide in 100 ml of dimethylformamide give 6.8 g (74%) of title compound as a fluffy, white solid, mp 146°-147° C.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-156477aa11ad42a1b2595492db6d9d06
Source dataset
uspto-grants-1990_08
Patent number
US04950674

Reaction notes

Loading…