Potassium Iodide → HCID 15093867, compound

HRID 1709932Notes

Reaction equation

HRID 1709932 reaction equation
C(O)(=O)C(O)=O.C1(C(C2C=CC=CC=2)=C2CCN(CCCOC3C=CC=CC=3)CC2)C=CC=CC=1.[F:36][C:37]1[CH:38]=[C:39]([C:44]([C:52]2[CH:57]=[CH:56][C:55]([F:58])=[C:54]([F:59])[CH:53]=2)([CH:46]2[CH2:51][CH2:50][NH:49][CH2:48][CH2:47]2)[OH:45])[CH:40]=[CH:41][C:42]=1[F:43].Cl[CH2:61][CH2:62][CH2:63][O:64][C:65]1[CH:70]=[CH:69][C:68]([C:71](=[O:73])[CH3:72])=[CH:67][C:66]=1[O:74][CH3:75].C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+]>C(O)CCC.CC(O)C>[F:59][C:54]1[CH:53]=[C:52]([C:44]([C:39]2[CH:40]=[CH:41][C:42]([F:43])=[C:37]([F:36])[CH:38]=2)([OH:45])[CH:46]2[CH2:51][CH2:50][N:49]([CH2:61][CH2:62][CH2:63][O:64][C:65]3[CH:70]=[CH:69][C:68]([C:71](=[O:73])[CH3:72])=[CH:67][C:66]=3[O:74][CH3:75])[CH2:48][CH2:47]2)[CH:57]=[CH:56][C:55]=1[F:58]

Participants

8

Reactant 5

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 73142644-(3-Chloropropoxy)-3-methoxyacetophenoneHCID 19992282HCID 19992282, compoundHCID 230363354-(Diphenylmethylene)-1-(3-phenoxypropyl)piperidine oxalate

Product 1

HCID 15093867HCID 15093867, compoundYield 50.4%

Reagents, catalysts & solvents 2

HCID 2631-ButanolSolventHCID 3776IsopropanolSolvent

Procedure

This compound was prepared according to the procedure used to synthesize the compound of Example 1. A mixture of 1.4 g (0.004 mole) of α,α-bis(3,4-difluorophenyl)-4-piperidinemethanol, 1.0 g (0.004 mole) of 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone, 1.6 g (0.015 mole) of anhydrous sodium carbonate and 0.4 g of potassium iodide in 100 ml of 1-butanol gave 1.1 g (48%) of the title compound as an off-white solid, mp 143°-146° C. (2-propanol).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-4257a6e9ded945cb8a4a60831387cc49
Source dataset
uspto-grants-1990_08
Patent number
US04950674

Reaction notes

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