Ammonium Acetate → HCID 23035024, compound

HRID 1709941Notes

Reaction equation

HRID 1709941 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][C:13](=O)[CH3:14])=[CH:8][CH:7]=1.C([O-])(=O)C.[NH4+].C([BH3-])#[N:22].[Na+]>CO>[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH:13]([NH2:22])[CH3:14])=[CH:8][CH:7]=1

Participants

5

Reactant 3

HCID 517165Ammonium AcetateHCID 5003444Sodium cyanoborohydrideHCID 22168537HCID 22168537, compound

Product 1

HCID 23035024HCID 23035024, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 1.36 g sample of 4-(3-chloropropoxy)phenylacetone, prepared above, was dissolved in 200 mL of methanol. To this was added 7.71 g of ammonium acetate followed by 0.76 g sodium cyanoborohydride with stirring. After 5 hours, the solvent was evaporated in vacuo, the residue was dissolved in 150 mL diethylether and 200 ml of 1 N hydrochloric acid solution. The aqueous phase was separated and washed with a second portion of diethylether, basified to a pH of 10-12 with 6 N sodium hydroxide, and extracted with three, 100 mL portions of diethylether. The basic ether extracts were

Workup

  1. customthe solvent was evaporated in vacuo
  2. dissolutionthe residue was dissolved in 150 mL diethylether
  3. customThe aqueous phase was separated
  4. washwashed with a second portion of diethylether
  5. extractionextracted with three, 100 mL portions of diethylether

Sources & evidence

ORD record
ord-6d93532bd3044ed7991b98ea34d46895
Source dataset
uspto-grants-1990_08
Patent number
US04952336

Reaction notes

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